May 22,334 BC – The Macedonian army of Alexander the Great defeated Darius III of Persia in the Battle of the Granicus. 1176 The Hashshashin (Assassins) attempted to murder Saladin near Aleppo. 1377 Pope Gregory XI issued five papal bulls to denounce the doctrines of English theologian John Wycliffe. 1455 Wars of the Roses: at the First Battle of St Albans, Richard, Duke of York, defeated and captured King Henry VI of England.
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